Results and molecular correlates from a pilot study of neoadjuvant induction FOLFIRINOX followed by chemoradiation and surgery for gastroesophageal adenocarcinomas

CONCLUSIONS: Here we show neoadjuvant FOLFIRINOX followed by CRT for locally advanced GEA is feasible and yields a high rate of pCR. ctDNA appears to be a promising predictor of postoperative recurrence.PMID:34330715 | DOI:10.1158/1078-0432.CCR-21-0331

Source: Clinical Cancer Research - July 31, 2021 Category: Cancer & Oncology Authors: Jennifer Y Wo Jeffrey W Clark Christine E Eyler Mari Mino-Kenudson Samuel J Klempner Jill N Allen Florence K Keane Aparna R Parikh Eric Roeland Lorraine C Drapek David P Ryan Ryan B Corcoran Emily Van Seventer Isobel J Fetter Heather A Shahzade Melin J Kh Source Type: research