GSE86117 The role of PSPH in melanoma progression

Contributors : Parmanand Malvi ; Narendra WajapeyeeSeries Type : Expression profiling by arrayOrganism : Homo sapiensPhosphoserine phosphatase (PSPH) has been shown to be important for progression of several tumors. PSPH expression is elevated in multiple cancer types including cutaneous melanoma. Therefore, we analyzed the role of PSPH in melanoma. Inhibition of PSPH in melanoma cell lines resulted in decreased proliferation, decreased invasion, and increased cell death. PSPH expression is regulated through MAP kinase pathway and inhibition of MAPK pathway leads to diminished PSPH expression.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research