Cancers, Vol. 13, Pages 3885: Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy

Cancers, Vol. 13, Pages 3885: Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy Cancers doi: 10.3390/cancers13153885 Authors: Luana Madalena Sousa Jani Sofia Almeida Tânia Fortes-Andrade Manuel Santos-Rosa Paulo Freitas-Tavares José Manuel Casanova Paulo Rodrigues-Santos Soft Tissue Sarcomas (STS) are a heterogeneous and rare group of tumors. Immune cells, soluble factors, and immune checkpoints are key elements of the complex tumor microenvironment. Monitoring these elements could be used to predict the outcome of the disease, the response to therapy, and lead to the development of new immunotherapeutic approaches. Tumor-infiltrating B cells, Natural Killer (NK) cells, tumor-associated neutrophils (TANs), and dendritic cells (DCs) were associated with a better outcome. On the contrary, tumor-associated macrophages (TAMs) were correlated with a poor outcome. The evaluation of peripheral blood immunological status in STS could also be important and is still underexplored. The increased lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR), higher levels of monocytic myeloid-derived suppressor cells (M-MDSCs), and Tim-3 positive CD8 T cells appear to be negative prognostic markers. Meanwhile, NKG2D-positive CD8 T cells were correlated with a better outcome. Some soluble factors, such as cytokines, chemokines, growth factors, and immune checkpoints were associated with the prognosis. Similarly, t...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research