Perfluoroalkyl Substance Exposure and the BDNF Pathway in the Placental Trophoblast

ConclusionsBDNF receptors are present in different regions of human placental villi, indicating diverse functions of BDNF signaling in placental development. Our findings suggest that the BDNF pathway in placental trophoblast cells is not disrupted by exposures to PFOS, PFOA, PFBS, and a PFAS mixture, but may be affected by PFNA exposures. Further investigation is needed on how PFAS affects other critical signaling pathways during fetal neurodevelopment.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research