Comprehensive analysis of a new prognosis signature based on histone deacetylases in clear cell renal cell carcinoma

Risk model consisting of HDAC8, HDAC10, and HDAC11  have a favorable role of risk prediction in ccRCC. Immune-associated functions and pathways were enriched in HDACs, and most of HDACs are related to tumor stemness, stromal cell, and immune cells. Several clinical characteristics are associated with HDACs expression and the activity of some common ly used drugs (such as oxaliplatin, vorinostat, temsirolimus) are also influenced by HDACs. AbstractHistone deacetylases (HDAC) family is vital for tumorigenesis and tumor progression. However, the exact role of the HDAC family in clear cell renal cell carcinoma (ccRCC) remains unclear. Based on The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and The Human Protein Atlas (HPA) database, we investigated and validated the expression profile, clinical significance and prognostic value of HDAC family members in ccRCC. Moreover, we further explored the correlation between HDACs and tumor microenvironment, tumor stemness, drug activity and immune subtype. TheHDAC8,HDAC10, andHDAC11 manifested potential clinical value for prognosis, and the correlation analyses reveals underlying molecular mechanisms, which deserve further investigation for ccRCC. This Integrated bioinformatics analysis, based on transcriptomics and proteomics, implied thatHDAC8,HDAC10, andHDAC11 may serve as potential molecular biomarkers and therapeutic targets for ccRCC, but some underlying molecular mechanisms still need to be elucidat...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research