Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy

This article mainly summarizes the factors that induce IDD and apoptosis, the relationship between the three apoptotic pathways and IDD, and potential therapeutic strategies. Preliminary animal and cell experiments show that targeting apoptotic pathway genes or drug inhibition can effectively inhibit IVD cell apoptosis and slow IDD progression. Targeted apoptotic pathway inhibition may be an effective strategy to alleviate IDD at the gene level. This manuscript provides new insights and ideas for IDD therapy.PMID:34220308 | PMC:PMC8241771 | DOI:10.7150/ijms.59171

Source: International Journal of Medical Sciences - July 5, 2021 Category: Biomedical Science Authors: Xiao-Bo Zhang Yi-Cun Hu Peng Cheng Hai-Yu Zhou Xiang-Yi Chen Ding Wu Rui-Hao Zhang De-Chen Yu Xi-Dan Gao Jin-Tao Shi Kai Zhang Shao-Long Li Peng-Jie Song Ke-Ping Wang Source Type: research