Neurological and developmental outcomes following neonatal encephalopathy treated with therapeutic hypothermia

In randomised trials, therapeutic hypothermia is associated with reduced prevalence of the composite outcome mortality or neurodevelopmental morbidity in neonates with neonatal encephalopathy (NE). Following systematic review, the reduction in prevalence of both mortality and infant neuromorbidity is clear. Among three trials reporting school age outcomes, the effects of NE and TH suggest that such benefit persists into middle childhood, but none of the major trials were powered to detect differences in these outcomes.

Source: Seminars in Fetal and Neonatal Medicine - July 25, 2021 Category: Perinatology & Neonatology Authors: Neil Marlow, Seetha Shankaran, Elizabeth E. Rogers, Nathalie L. Maitre, Christopher D. Smyser, Newborn Brain Society Guidelines and Publications Committee Source Type: research