Lineage Contribution of PDGFR < em > α < /em > -Expressing Cells in the Developing Mouse Eye

In this study, we aim to present a detailed PDGFRα expression and lineage map from early embryogenesis to adulthood. PDGFRα-CreER; mT/mG reporter mice were analyzed. mEGFP-positive cells contributed to multiple ocular lineages in a spatiotemporally regulated manner. A dynamic PDGFRα expression was identified in corneal stromal cells, lens epithelial cells, lens fiber cells, and retinal astrocytes during the entire period of eye development, while PDGFRα expression in retinal astrocytes from E17.5 onwards and in Müller glial cells was identified within two weeks after birth. By revealing detailed characterization of gene expression and function, we present a comprehensive map of PDGFRα-expressing cells in the eye for a better understanding of PDGFRα signaling's role during eye development.PMID:34285913 | PMC:PMC8275403 | DOI:10.1155/2021/4982227

Source: Biomed Res - July 21, 2021 Category: Research Authors: Deyi Zhuo Yumei Diao Xiaoqi Li Yifei Huang Liqiang Wang Source Type: research