Antibiotic-induced disruption of the microbiome exacerbates chemotherapy-induced diarrhoea and can be mitigated with autologous faecal microbiota transplantation

Chemotherapy is well documented to disrupt the gut microbiome, leading to poor treatment outcomes and a heightened risk of adverse toxicity. Although strong associations exist  between its composition and gastrointestinal toxicity, its causal contribution remains unclear. Our inability to move beyond association has limited the development and implementation of microbial-based therapeutics in chemotherapy adjuncts with no clear rationale of how and when to deliver them.

Source: European Journal of Cancer - June 12, 2021 Category: Cancer & Oncology Authors: Hannah R. Wardill, Stijn A.R. van der Aa, Ana R. da Silva Ferreira, Rick Havinga, Wim J.E. Tissing, Hermie J.M. Harmsen Tags: Original Research Source Type: research