Sex differences in antibody responses to the 23-valent pneumococcal polysaccharide vaccination
There are profound sex-based differences in both humoral and cellular immune responses to vaccination [1]. In general, adult females demonstrate higher antibody responses to bacterial and viral vaccines than men [2]. For instance, adult females vaccinated with half the dose of the trivalent inactivated influenza vaccine (TIV) produce similar humoral immune responses than adult males vaccinated with a full dose of the TIV [3]. Given that the 23-valent pneumococcal polysaccharide vaccine (PPSV23) is an important tool in our evaluation of the humoral immune response [4], we sought to determine if men and women have a significantly different immunoglobulin G (IgG) antibody response to PPSV23.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Sergio E. Chiarella, Sarah M. Jenkins, Miguel A. Park, Roshini S. Abraham, Avni Y. Joshi Tags: Letters Source Type: research
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