Safety, Efficacy, and Cost of 0.4-mg Versus 2-mg Intranasal Naloxone for Treatment of Prehospital Opioid Overdose

CONCLUSION AND RELEVANCE: Treatment of prehospital opioid overdose using intranasal naloxone at an initial dose of 0.4 mg was equally effective during the prehospital period as treatment at an initial dose of 2 mg, was associated with a lower rate of adverse effects, and represented a 79% reduction in cost.PMID:34229467 | DOI:10.1177/10600280211030918

Source: The Annals of Pharmacotherapy - July 7, 2021 Category: Drugs & Pharmacology Authors: John Thompson Jenna Salter Peter Bui Logan Herbert David Mills Deborah Wagner Christine Brent Source Type: research