Enhancer-associated long noncoding RNAs: A novel frontier with new perception in cardiac regeneration

Heart is the first organ to form and function during embryogenesis; nonetheless, its patho- physiological complications still remain eminent. Heart failure (HF) is not only a major health concern of the present population but also an emerging threat for future generations [1]. Its global mortality and morbidity has pressed scientists to attain better understanding about the molecular basis of this disease. Postnatal heart shows lower rate of cardiomyocyte proliferation. Moreover, following cardiac injury, the poor regenerative potential combined with progressive loss of cardiomyocytes leads to heart failure.

Source: Trends in Cardiovascular Medicine - February 23, 2015 Category: Cardiology Authors: Prince Jeyabal, Rajarajan Amirthalingam Thandavarayan, Sahana Suresh Babu, Prasanna Krishnamurthy Source Type: research