Nonphosphorylatable PEA15 mutant inhibits epithelial-mesenchymal transition in triple-negative breast cancer partly through the regulation of IL-8 expression

ConclusionsOur results show that PEA15 phosphorylation status serves as an important regulator for PEA15 ’s dual role as an oncogene or tumor suppressor and support the potential of PEA15-AA as a therapeutic strategy for treatment of TNBC.

http://link.springer.com/10.1007/s10549-021-06316-2

Source: Breast Cancer Research and Treatment - July 9, 2021 Category: Cancer & Oncology Source Type: research