Rare genetic defect replicated in fish model

(University of Heidelberg) A rare genetic defect that affects the so-called ALG2 gene can cause serious metabolic diseases in humans. Until now, its rareness and complexity made it difficult to study this congenital glycosylation disorder. A research team from the Centre for Organismal Studies (COS) of Heidelberg University has finally succeeded in introducing the underlying mutation in the ALG2 gene in a fish model, allowing the causes of these complex diseases to be studied at the molecular level.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news