Glioma associated microglia/macrophages distribution is conserved in glioblastoma regrowth: a morphometric study

Cancer Invest. 2021 Jun 21:1-14. doi: 10.1080/07357907.2021.1944179. Online ahead of print.ABSTRACTWe compared the morphological aspect of glioblastoma associated microglia/macrophages cells in 15 paired recurrent glioblastomas to check the ability of glioblastoma to recreate its microenvironment. The absolute number of GAMs is lower in normal tissue (21/mm2) than in the isolated tumor cells area (100-112/mm2) than in the solid tumor area (212-220/mm2) (p < 0.01). The morphology of GAMs remained the same in each tumor area with a reduced covered area by cell processes (196 to 216/mm2) than in normal tissue (708/mm2) (p < 0.01). In paired tumors, GAMs morphology remained the same in successive resections and was not modified by the treatments.PMID:34151673 | DOI:10.1080/07357907.2021.1944179
Source: Cancer Investigation - Category: Cancer & Oncology Authors: Source Type: research