Application of Immune Checkpoint Inhibitors in Solid Organ Transplantation Recipients: A Systematic Review

ConclusionsOur systematic review summarizes the use of ICIs in SOTRs and evaluates the efficacy of ICIs and the risk factors that induce HVGR. Through risk factor analysis, we found that mTOR inhibitors and calcineurin inhibitors may help to reduce the occurrence of HVGR;  hormones and anti-metabolic drugs may have adverse effects on the efficacy of ICIs. In addition, there is a contradictory relationship between the occurrence of HVGR and the efficacy of ICIs.
Source: Interdisciplinary Sciences, Computational Life Sciences - Category: Bioinformatics Source Type: research