A myriad of roles of dendritic cells in atherosclerosis

Clin Exp Immunol. 2021 Jun 10. doi: 10.1111/cei.13634. Online ahead of print.ABSTRACTAtherosclerosis is an inflammatory disease with break-down of homeostatic immune regulation of vascular tissues. As critical initiator of host immunity, dendritic cells (DCs) have been identified in the aorta of healthy individuals and atherosclerotic patients as well, whose roles in regulating the arterial inflammation aroused great interests. Accumulating evidences have now pointed to the fundamental roles for DCs in every developmental stages of atherosclerosis due to their myriads of functions in immunity and tolerance induction ranging from lipid uptake, efferocytosis and antigen presentation to pro-, and anti-inflammatory cytokine or chemokine secretion. We hereby made a timely summary of the published works in this field, and comprehensively discussed both direct and indirect roles of DCs in the atherogenesis. Understanding the pathogenic roles of DCs during the development of atherosclerosis in vascular tissues would surely help open therapeutic avenue to the treatment of cardiovascular diseases.PMID:34109619 | DOI:10.1111/cei.13634
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Source Type: research