Relevance of plasma matrix metalloproteinase-9 for bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplantation: Plasma MMP-9 in BOS

Bronchiolitis obliterans syndrome (BOS) is a highly morbid form of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). BOS also occurs after lung transplantation and is characterized by peribronchial fibrosis and intraluminal obstruction of the small terminal airways, resulting in airflow obstruction.1 At least 3 plasma proteins, matrix metalloproteinase-9 (MMP-9), MMP-3 and chitinase-3-like1 glycoprotein (YKL-40), have been identified as biomarkers for BOS after lung transplantation.

https://www.astctjournal.org/article/S2666-6367(21)00956-8/fulltext?rss=yes

Source: Biology of Blood and Marrow Transplantation - June 11, 2021 Category: Hematology Authors: Yoshihiro Inamoto, Paul J. Martin, Lynn E. Onstad, Guang-Shing Cheng, Kirsten M. Williams, Iskra Pusic, Vincent T. Ho, Mukta Arora, Joseph Pidala, Mary E.D. Flowers, Ted A. Gooley, Richard L. Lawler, John A. Hansen, Stephanie J. Lee Source Type: research