Adult Age Differences in Self-Reported Pain and Anterior CSF Space in Chiari Malformation

The objective of this study was to better understand the relationships among these variables using causal modeling techniques. Adult CMI patients (80% female) who either had (n = 150) or had not (n = 151) undergone posterior fossa decompression surgery were assessed using morphometric measures derived from magnetic resonance images (MRI). MRI-based morphometry showed that the area of the CSF pocket anterior to the cervico-medullary junction (anterior CSF space) correlated with age at the time of MRI (r =  − .21). Also, self-reported pain increased with age (r = .11) and decreased with anterior CSF space (r =  − .18). Age differences in self-reported pain were mediated by anterior CSF space in the cervical spine area—and this effect was particularly salient for non-decompressed CMI patients. As CMI patients age, the anterior CSF space dec reases, and this is associated with increased pain—especially for non-decompressed CMI patients. It is recommended that further consideration of age-related decreases in anterior CSF space in CMI patients be given in future research.
Source: The Cerebellum - Category: Neurology Source Type: research