Multi-omics analysis identifies CpGs near G6PC2 mediating the effects of genetic variants on fasting glucose

Conclusions/interpretationOur analysis results suggest that rs2232326 and rs2232328 inG6PC2 may affect DNA methylation at CpGs near the gene and that the methylation may have downstream effects on fasting glucose. Therefore, SNPs inG6PC2 and CpGs nearG6PC2 may reside along the pathway that influences fasting glucose levels. This is the first study to report CpGs nearG6PC2, an important gene for regulating insulin secretion, mediating the effects of GWAS-significant SNPs on fasting glucose.Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research