Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes

Conclusions/interpretationWe demonstrate a novel feature of pancreas pathology in type 1 diabetes. TLOs represent a potential site of autoreactive effector T cell generation in islet autoimmunity and our data from mouse and human tissues suggest that they disappear once the destructive process has run its course. Thus, TLOs may be important for type 1 diabetes progression.Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research