Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis [Neuroscience]

Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease characterized by myelin damage followed by axonal and ultimately neuronal loss. The etiology and physiopathology of MS are still elusive, and no fully effective therapy is yet available. We investigated the role in MS of autophagy (physiologically, a controlled intracellular pathway...

http://www.pnas.org/content/118/24/e2020078118.short?rss=1

Source: Proceedings of the National Academy of Sciences - June 7, 2021 Category: Science Authors: Simone Patergnani, Massimo Bonora, Selene Ingusci, Maurizio Previati, Saverio Marchi, Silvia Zucchini, Mariasole Perrone, Mariusz R. Wieckowski, Massimiliano Castellazzi, Maura Pugliatti, Carlotta Giorgi, Michele Simonato, Paolo Pinton Tags: Neuroscience Biological Sciences Source Type: research