Nanodiamond-chitosan functionalized hernia mesh for biocompatibility and antimicrobial activity

J Biomed Mater Res A. 2021 Jun 3. doi: 10.1002/jbm.a.37237. Online ahead of print.ABSTRACTPolypropylene (PP) mesh is most commonly used for the treatment of hernia and pelvic floor construction. However, some of the patients have a few complications after surgery due to the rejection or infection of the implanted meshes. The poor biocompatibility of PP mesh, low wettability results in poor cell attachment/proliferation and restricts the loading of antibacterial agent, leading to a slow healing process and high risk of infection after surgery. Here in this study, a new technique has been employed to develop a novel antimicrobial and biocompatible PP mesh modified with bioactive chitosan and functionalized nanodiamond (FND) for infection inhibition and acceleration of the healing process. An oxygen plasma treatment PP mesh was used then chitosan was strongly attached to the surface of the PP fibers. Subsequently, FND as an antibacterial agent was loaded into the chitosan modified PP fiber to provide desired antibacterial functions. The meshes were characterised with XRD, FTIR, SEM, EDX, water contact angle, confocal, and optical microscopy. The modified PP mesh with chitosan and FND showed a significant increase in its hydrophilicity and L929 fibroblast cell attachment. Furthermore, the modified mesh exhibited great antibacterial efficiency against Escherichia coli. Therefore, the newly developed technique to modify PP mesh could be a promising technique to generate a biocompat...
Source: Biomed Res - Category: Research Authors: Source Type: research