Reproductive Toxicity of a Mixture of Regulated Drinking-Water Disinfection By-Products in a Multigenerational Rat Bioassay

Conclusions: A mixture of regulated DBPs at up to 2000× the MCLs had no adverse effects on fertility, pregnancy maintenance, prenatal survival, postnatal survival, or birth weights. Delayed puberty at ≥1000× may have been secondary to reduced water consumption. Male nipple retention and compromised sperm motility at 2000× may have been secondary to reduced body weights. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Narotsky MG, Klinefelter GR, Goldman JM, DeAngelo AB, Best DS, McDonald A, Strader LF, Murr AS, Suarez JD, George MH, Hunter ES 3rd, Simmons JE. Reproductive Toxicity of a Mixture of Regulated Drinking-Water Disinfection By-Products in a Multigenerational Rat Bioassay. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1408579. Received: 21 April 2014 Accepted: 12 February 2015 Advance Publication: 19 February 2015 Supplemental Material (405 KB) Article Views This Week: 151 Article Views This Year: 151 Share this Article
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research