Dibenzocyclooctadiene lignans from Artemisia sieversiana and their anti-inflammatory activities

This study is the first to report dibenzocyclooctadiene lignans in the genusArtemisia and this plant. All the compounds were evaluated for their anti-neuroinflammatory activities on the lipopolysaccharides (LPS)-induced nitric oxide production in BV-2 murine microglial cells. Compounds1 and6 exhibited the moderate activities with their IC50 values of 47.7 and 21.9  μM, compared to a positive control quercetin with the IC50 value of 16.0  μM.Graphic abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research