Dried Plasma Spots and Oral Fluid as Alternative Matrices for Therapeutic Drug Monitoring of Busulfan: Analytical Method Development and Clinical Evaluation

Conclusions: We developed and validated a simple and fast ultra–high-performance liquid chromatography–MS/MS assay to measure BU in oral fluid and DPS. The results do not support the use of oral fluid as a matrix for routine therapeutic drug monitoring of BU. The AUC estimated from BU measurements in DPS was comparable to that in plasma, supporting the use of DPS in BU therapeutic drug monitoring as an alternative matrix, with adequate short-term stability and logistic advantages.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Focus Series: Alternative Sampling Strategies Source Type: research