Genes, Vol. 12, Pages 749: Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer

Genes, Vol. 12, Pages 749: Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer Genes doi: 10.3390/genes12050749 Authors: Ritu Pandey Muhan Zhou Yuliang Chen Dalila Darmoul Conner C. Kisiel Valentine N. Nfonsam Natalia A. Ignatenko Colorectal cancer (CRC) remains one of the leading causes of cancer-related death worldwide. The high mortality of CRC is related to its ability to metastasize to distant organs. The kallikrein-related peptidase Kallikrein 6 (KLK6) is overexpressed in CRC and contributes to cancer cell invasion and metastasis. The goal of this study was to identify KLK6-associated markers for the CRC prognosis and treatment. Tumor Samples from the CRC patients with significantly elevated KLK6 transcript levels were identified in the RNA-Seq data from Cancer Genome Atlas (TCGA) and their expression profiles were evaluated using Gene Ontology (GO), Phenotype and Reactome enrichment, and protein interaction methods. KLK6-high cases had a distinct spectrum of mutations in titin (TTN), APC, K-RAS, and MUC16 genes. Differentially expressed genes (DEGs) found in the KLK6-overexpressing CRCs were associated with cell signaling, extracellular matrix organization, and cell communication regulatory pathways. The top KLK6-interaction partners were found to be the members of kallikrein family (KLK7, KLK8, KLK10), extracellular matrix associated proteins (keratins, integrins, small proline rich repeat, S100A families) and TGF-β...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research