Colonic Gene Expression and Fecal Microbiota in Diarrhea-predominant Irritable Bowel Syndrome: Increased Toll-like Receptor 4 but Minimal Inflammation and no Response to Mesalazine

CONCLUSIONS: Biopsies from a well-characterized IBS-D cohort showed no substantial inflammation. Mesalazine has little effect on gene expression and its previous reported effect on fecal microbiota associated with much greater inflammation found in inflammatory bowel diseases is likely secondary to reduced inflammation. Increased expression of TLR4 and correlated receptors in IBS may mediate a general increase in sensitivity to external stimuli, particularly those that signal via the TLR system.PMID:33795545 | PMC:PMC8026366 | DOI:10.5056/jnm20205

Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Jonna Jalanka Ching Lam Andrew Bennett Anna Hartikainen Fiona Crispie Laura A Finnegan Paul D Cotter Robin Spiller Source Type: research