Advances in the Development of Biomarkers for Poststroke Epilepsy

Biomed Res Int. 2021 Apr 17;2021:5567046. doi: 10.1155/2021/5567046. eCollection 2021.ABSTRACTStroke is the main cause of acquired epilepsy in elderly people. Poststroke epilepsy (PSE) not only affects functional recovery after stroke but also brings considerable social consequences. While some factors such as cortical involvement, hemorrhagic transformation, and stroke severity are associated with increased seizure risk, so far that remains controversial. In recent years, there are an increasing number of studies on potential biomarkers of PSE as tools for diagnosing and predicting epileptic seizures. Biomarkers such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), glutamate, and S100 calcium-binding protein B (S100B) in blood are associated with the occurrence of PSE. This review is aimed at summarizing the progress on potential biomarkers of PSE.PMID:33959658 | PMC:PMC8075663 | DOI:10.1155/2021/5567046
Source: Biomed Res - Category: Research Authors: Source Type: research