Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study

Conclusion: Renal impairment is an important risk factor for stroke, particularly in younger patients, and is associated with more severe stroke and worse outcomes.Neuroepidemiology
Source: Neuroepidemiology - Category: Epidemiology Source Type: research

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Annu Rev Physiol. 2021 Oct 26. doi: 10.1146/annurev-physiol-060821-014521. Online ahead of print.ABSTRACTCerebral small vessel disease (SVD) is highly prevalent and a common cause of ischemic and hemorrhagic stroke and dementia, yet the pathophysiology is poorly understood. Its clinical expression is highly varied, and prognostic implications are frequently overlooked in clinics; thus, treatment is currently confined to vascular risk factor management. Traditionally, SVD is considered the small vessel equivalent of large artery stroke (occlusion, rupture), but data emerging from human neuroimaging and genetic studies refut...
Source: Annual Review of Physiology - Category: Physiology Authors: Source Type: research
CONCLUSION: Obese patients are less likely to die during hospitalization following first-time non-subarachnoid hemorrhage and ischemic stroke than non-overweight/non-obese patients. These findings support the "obesity paradox" concept, though more research is needed for recurrent stroke patients.PMID:34691415 | PMC:PMC8519764 | DOI:10.1016/j.amsu.2021.102839
Source: Annals of Medicine - Category: Internal Medicine Authors: Source Type: research
CONCLUSIONS: High non-HDL-C levels were associated with an increased risk of myocardial infarction. Moreover, high and low non-HDL-C levels were associated with a high risk of stroke and its subtypes among Japanese workers.PMID:34690212 | DOI:10.5551/jat.63118
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Authors: Source Type: research
Rev Neurol (Paris). 2021 Oct 20:S0035-3787(21)00707-4. doi: 10.1016/j.neurol.2021.07.021. Online ahead of print.ABSTRACTAntithrombotic drugs (ADs) are the mainstay of secondary prevention of thrombotic vascular diseases. Management of patients under long-term treatment with ADs admitted for acute cerebrovascular disease, either ischemic stroke (IS) or intracerebral hemorrhage (ICH), has become a frequent situation that might influence decision-making processes from diagnosis to therapeutic strategies. The aim of this review is to summarize current data from the literature to help clinicians in their decisions for stroke ca...
Source: Revue Neurologique - Category: Neurology Authors: Source Type: research
CONCLUSIONS: Ginkgolide, working as PAF antagonist, may reduce recurrent stroke in AIS with ICAS patients within 72 hours after onset. It might be an optional treatment in moderate-to-severe AIS patients with ICAS. (http://www.chictr.org.cn Number as ChiCTR-IPR-17012310).PMID:34676982 | DOI:10.1111/cns.13742
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Source Type: research
CONCLUSION: There are few studies that analyse the incidence of CVD and even fewer that analyse its evolution. The overall median remains high, although the figures are heterogeneous across studies. Worldwide the trend is towards its decrease, and there are geographical areas, especially in Asia, with an alarming upward trend.PMID:34676530 | DOI:10.33588/rn.7309.2021138
Source: Revista de Neurologia - Category: Neurology Authors: Source Type: research
CONCLUSIONS: Since the last version of this review, four new relevant studies have been published, and conclusions remain consistent. People who have early anticoagulant therapy after acute ischaemic stroke do not demonstrate any net short- or long-term benefit. Treatment with anticoagulants reduced recurrent stroke, deep vein thrombosis, and pulmonary embolism but increased bleeding risk. Data do not support the routine use of any of the currently available anticoagulants for acute ischaemic stroke.PMID:34676532 | DOI:10.1002/14651858.CD000024.pub5
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research
Nuclear receptors of NR1 (VDR, RARs, PPARs, and LXRs) and NR4 (Nur77 and Nurr1) subfamilies inhibit the production of pro-inflammatory factors from microglia. Some of them also promote the production of anti-inflammatory cytokines and enhance the phagocytic activity of microglia. AbstractThis review provides an overview of researches on the NR1 and NR4 nuclear receptors involved in the regulation of microglial functions. Nuclear receptors are attractive candidates for drug targets in the therapies of the central nervous system disorders, because the activation of these receptors is expected to regulate the functions and th...
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: REVIEW Source Type: research
ConclusionsDespite the severity of the diseases included in MDC 1 (i.e. ischemic stroke, intracranial hemorrhage), a significant decline was detected in hospital admissions in Abruzzo. Subsequently, a high number of subjects might have not received the necessary health assistance leading to an increase in mortality and morbidity for these severe pathologies. Additionally, patients might have avoided seeking hospital care in response to the fear of contagion triggered either by media or as a result of the stay-at-home government recommendations.Key messagesAn alarming reduction in all types of hospitalizations for neurologi...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
Conclusion: Our results help to plan resources in thrombectomy-capable centers in times of expanding indications for EVT where resources will have to be adjusted to patients with low-NIHSS, low-ASPECTS, and distal occlusions, and patients presenting in the extended time window, which may altogether account for an additional 20% of all ischemic stroke patients.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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