Unique pathological findings of astroblastoma with MN1 alteration in a patient with late recurrence

We report a late recurrence ofMN1-altered astroblastoma with unique pathological findings. A 24-year-old woman presented with seizures due to a left frontal lobe tumor. Gross total resection (GTR) was achieved, and the diagnosis wasMN1-altered astroblastoma, which presented cell wrapping, i.e., presence of tumor cells enveloping one another. She received local radiotherapy (50  Gy). However, the tumor recurred after 12 years, and its size increased rapidly. The second surgery achieved GTR and confirmed increasing anaplasia. The patient was tumor-free for 1 year without any neurological deficits. This case implies the importance of long-term follow-up ofMN1-altered astroblastoma. The pathological significance of cell wrapping in this case is unclear, but it may be associated withMN1-altered astroblastoma and should be noted in future cases.
Source: Brain Tumor Pathology - Category: Neurology Source Type: research