P187  Secukinumab significantly decreased joint synovitis measured by Power Doppler ultrasonography in biologic-naive patients with active psoriatic arthritis: primary (12week) results from a randomised, placebo-controlled Phase 3 study

Conclusion Secukinumab demonstrated a rapid and significant decrease in synovitis over 12 weeks (per GLOESS), and superior efficacy on ACR20/50 responses and SPARCC enthesitis vs placebo at Week 12 in biologic-naive patients with PsA. The safety profile of secukinumab was consistent with previous reports.Disclosure M. D'Agostino: Honoraria; M-A.D has received speaker/consultancy fees from Sanofi, Novartis, BMS, Celgene, Roche, AbbVie, UCB and Eli Lilly.G. Schett: Honoraria; G.S. has received honoraria from AbbVie, BMS, Celgene, Janssen, Lilly, Novartis, Roche and UCB.A. L ópez Rodríguez: Corporate appointments; A.L.R. is a clinical trial researcher, speaker and consultant for Roche, Eli Lilly, Novartis, BMS and Neovacs.L. Šenolt: Honoraria; L.S. has received speaker's honoraria from AbbVie, Amgen, BMS, Celgene, Eli Lilly, MSD, Novartis, Pfizer, Roche and UCB., L.S. has received expenses for attendance at advisory board meetings from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche and UCB., L.S. has received honoraria for clinical trials from AbbVie, Amgen, BMS, Celgene, Novartis, Pfizer, Takeda and UCB. Grants/research support; L.S. has received research grants from AbbVie.J. Maldonado-Cocco: Consultancies; J.M-C. is a speaker/consultant for Pfizer, Merck Sharp& Dohme, Sanofi-Aventis, Novartis, BMS, Roche, Boehringer Ingelheim, Schering-Plough, Abbott, UCB, Eli Lilly and Gilead. Other; J.M-C. is a clinical researcher as PI in clinical trials for Pfizer, Merck Sh...
Source: Rheumatology - Category: Rheumatology Source Type: research