A study of association of urinary nephrin with albuminuria in patients with diabetic nephropathy

Conclusion: Albuminuria has been used as an independent predictor of diabetic nephropathy. The statistical significant difference between the groups inferred that urinary nephrin excretion increased even in the stage of normoalbuminuria. Nephrin expression and its phosphorylation get altered by hyperglycaemia, contributing to renal damage. Nephrin was found to be a sensitive marker of early kidney dysfunction in diabetic patients.
Source: Indian Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research