The reduction of two BRCA1 gene mutations frequencies in ovarian cancer patients from Ukraine

Publication date: Available online 16 April 2021Source: Meta GeneAuthor(s): Ielizaveta Gorodetska, Mariia Inomistova, Natalia Khranovska, Oksana Skachkova, Yurii Michailovich, Luydmila Rybchenko, Anna Bychkova, Anna Stefanovich, Bogdana Klimuk, Larysa Poluben, Sergiy Klymenko, Zoia Rossokha, Svitlana Kyriachenko, Olena Popova, Nataliia Gorovenko, Olga Ponomarova, Iryna Kozeretska
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research

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Publication date: Available online 8 October 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Thomas Boerner, Kara Long Roche
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionsOur findings revealed that the Warburg and reverse Warburg effects coexisted in human ovarian cancer tissues, provided the first multiomics-based molecular alteration spectrum of ovarian cancer energy metabolism pathways (aerobic glycolysis, Kreb ’s cycle, oxidative phosphorylation, and lactate shuttle), and demonstrated that the antiparasite drug ivermectin effectively regulated these changed molecules in energy metabolism pathways and had strong capability to inhibit cell proliferation and cell cycle progression and promote cell apoptosi s in ovarian cancer cells. The observed molecular changes in energy...
Source: EPMA Journal - Category: International Medicine & Public Health Source Type: research
Conditions:   Ovarian Cancer;   Clinical Marker;   PARP Inhibitor Intervention:   Drug: PARP inhibitors Sponsor:   Xiaoxiang Chen Recruiting
Source: - Category: Research Source Type: clinical trials
Background: Epithelial ovarian cancer (EOC) has been classified into four molecular subtypes, of which the mesenchymal subtype has the poorest survival. Our goal is to develop an immune-based prognostic signature by incorporating molecular subtypes for EOC patients. Methods: The gene expression profiles of EOC samples were collected from seven public datasets as well as an internal retrospective validation cohort, containing 1192 EOC patients. Network analysis was applied to integrate the mesenchymal modalities and immune signature to establish an immune-based prognostic signature for EOC (IPSEOC). The signature was t...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
When the drug Taxol® was approved by the United States Food and Drug Administration in 1993, it was a game changer for cancer patients. The compound, which arrests cell division by preventing the disassembly of tubulin microfibers, has been used over the past three decades to treat millions of cases of breast, lung, and ovarian cancer as well as Kaposi's sarcoma. In 1990, Bristol Myers Squibb applied to trademark the name Taxol, which was approved in 1992, changing the drug's generic name to paclitaxel.At the time that Taxol was entering clinical trials in the late 1970s, it also proved to be a valuable tool for cytosk...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Classics Source Type: research
High-grade serous carcinoma (HGSC) is the most prevalent and aggressive subtype of ovarian cancer. The large degree of clinical heterogeneity within HGSC has justified deviations from the traditional one-size-...
Source: Journal of Hematology and Oncology - Category: Hematology Authors: Tags: Review Source Type: research
The current life expectancy of females in the United Kingdom is estimated to be 82.9 years [1], and the average age of menopause is 51 years [2]. Women in the UK therefore spend around one-third of their life in the menopausal state. The timing of menopause influences future health outcomes, such that an early age at menopause increases risk of bone fractures and cardiovascular diseases while an increased risk of breast, ovarian and endometrial cancer have been associated with a late onset of menopause [3].
Source: Maturitas - Category: Primary Care Authors: Source Type: research
AbstractWe evaluated the effectiveness, safety and efficacy of robotic interval debulking surgery (IDS) in advanced epithelial ovarian cancer (EOC) treated with neoadjuvant chemotherapy (NACT). We conducted a systematic review of the published relevant studies. Α total of 102 patients were evaluated. Mean operative time ranged from 164 to 312 min (mean ± SD: 246 ± 61 min) while mean estimated blood loss ranged from 106.9 to 262.5 ml (mean ± SD: 168 ± 68 ml) and postoperative blood transfusion rate was 19% (n&thinsp...
Source: Journal of Robotic Surgery - Category: Surgery Source Type: research
AbstractThere has been a rapid advance in germline multigene panel testing by next-generation sequencing, and it is being widely used in clinical settings. A 56-year-old woman suspected of having Lynch syndrome was identified as aBRCA2 pathogenic variant carrier by multigene panel testing. The patient was diagnosed with endometrial cancer at the age of 39  years, and total laparoscopic hysterectomy and bilateral salpingectomy were performed at the age of 49 years; however, bilateral oophorectomy was not performed at that time. As she had a family history of colorectal cancer and a history of endometrial cancer, L...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
tRNA fragments (tRFs) are a class of small non-coding RNAs (sncRNAs) derived from tRNAs. tRFs are highly abundant in many cell types including stem cells and cancer cells, and are found in all domains of life. Beyond translation control, tRFs have several functions ranging from transposon silencing to cell proliferation control. However, the analysis of tRFs presents specific challenges and their biogenesis is not well understood. They are very heterogeneous and highly modified by numerous post-transcriptional modifications. Here we describe a bioinformatic pipeline (tRFs-Galaxy) to study tRFs populations and shed light on...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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