Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma

Conditions:   Adult Anaplastic Astrocytoma;   Adult Anaplastic Ependymoma;   Adult Anaplastic Oligodendroglioma;   Adult Brain Stem Glioma;   Adult Ependymoblastoma;   Adult Giant Cell Glioblastoma;   Adult Glioblastoma;   Adult Gliosarcoma;   Adult Mixed Glioma;   Adult Pineal Gland Astrocytoma;   Recurrent Adult Brain TumorInterventions:   Biological: IL13Rα2-specific, hinge-optimized, 41BB-costimulatory CAR/truncated CD19-expressing T lymphocytes;   Other: laboratory biomarker analysis;   Other: quality-of-life assessmentSponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)Not yet recruiting - verified January 2015
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials