The Evaluation of the Relation between Bladder Cancer and Oxidative Stress Using NRF-2/KEAP-1 Pathway, Zinc and Copper Levels

Urol J. 2021 Apr 11:6439. doi: 10.22037/uj.v18i.6439. Online ahead of print.ABSTRACTPURPOSE: It has been shown that the Copper and Zinc contribute to the structure of the antioxidant enzymes. In addition NRF-2 and KEAP-1 complex have powerful effect on the intracellular organization of the antioxidants. We evaluated the relation of Copper, Zinc, NRF-2 and KEAP-1 complex regarding to the oxidative stress with tumor stage - grade in patients with bladder cancer.MATERIALS AND METHODS: A total of 52 patients (32 bladder cancer and 20 control group) were included to the study. The demographic properties of groups were identical. Serum NRF-2, KEAP-1, Cu and Zn levels were compared by ELISA method between the groups and tissue NRF-2, KEAP-1, Cu and Zn levels were evaluated also by ELISA method at cancer patients.PMID:33840087 | DOI:10.22037/uj.v18i.6439
Source: Urology Journal - Category: Urology & Nephrology Authors: Source Type: research