Investigating Intestinal Transporter Involvement in Rivaroxaban Disposition through Examination of Changes in Absorption

ConclusionThese analyses indicate that inhibition of efflux transporters appears to have negligible, clinically insignificant effects on the rivaroxaban absorption process, which is consistent with the concern that predictions based onin vitro measures may not translate to a clinically relevant interactionin vivo. We emphasize the need to evaluate gastric emptying, dissolution and other processes related to absorption when usingMAT changes to indicate efflux transporter inhibition.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research