Diacylglycerol kinase α inhibition cooperates with PD-1-targeted therapies to restore the T cell activation program

ConclusionsOur results indicate that DGKα inhibition could provide an important mechanism to revert exhausted T lymphocyte phenotypes and thus favor proper anti-tumor T cell responses. The cooperative effect observed after PD-1/PD-L1 and DGKα blockade offers a promising strategy to improve the efficacy of immunotherapy in the treatment of cancer.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research