Comment on "Tumor-initiating cells establish an IL-33-TGF-{beta} niche signaling loop to promote cancer progression"

Taniguchi et al. (Research Articles, 17 July 2020, p. 269) claim that the cytokine interleukin-33 induces accumulation of tumor-associated macrophages expressing the immunoglobulin E receptor FcRI. Although these findings hold great therapeutic promise, we provide evidence that the anti-FcRI antibody used in this study is not specific for FcRI on macrophages, which raises concerns about the validity of some of the conclusions.

Source: ScienceNOW - April 8, 2021 Category: Science Authors: Kamphuis, J. B. J., Worrall, W. P. M., Stackowicz, J., Mougel, A., Maure, E., Conde, E., Bruhns, P., Guilleminault, L., Gaudenzio, N., Chen, J., Gentek, R., Reber, L. L. Tags: Immunology, Medicine, Diseases t-comment Source Type: news