Conjugated hyperbilirubinemia among infants with hyperinsulinemic hypoglycemia

Conclusions: A significant percentage of infants with hyperinsulinism develop idiopathic, spontaneously resolving, conjugated hyperbilirubinemia. The association with a history of fetal distress potentially suggests that intrauterine factors leading to hyperinsulinism may also predispose towards conjugated hyperbilirubinemia. While the presence of neonatal cholestatic jaundice warrants timely investigations to exclude important underling etiologies, if validated, these findings may support a less invasive diagnostic workup of conjugated hyperbilirubinemia in infants with co-existent hyperinsulinism.What is Known:•Hyperinsulinism and conjugated hyperbilirubinemia are two common presentations in neonates.•A clinical association between the two conditions has not been described.What is New:•A significant proportion of infants with hyperinsulinism develop idiopathic, spontaneously resolving conjugated hyperbilirubinemia.•Increased risk for cholestasis in this patient population is associated with fetal distress and prematurity but not parental nutrition.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research