Tau oligomers accumulation sensitizes prostate cancer cells to docetaxel treatment

CONCLUSIONS: Our data indicate that autophagy could exert a promoting role in cancer growth and during chemotherapy facilitating degradation of tau protein and thus blocking the antimitotic effect of accumulated tau oligomers. Thus, therapeutic strategies aimed at stimulating tau oligomers formation, such as autophagy inhibition, could be an effective adjuvant in cancer therapy.PMID:33811272 | DOI:10.1007/s00432-021-03598-3

Source: Clinical Prostate Cancer - April 3, 2021 Category: Cancer & Oncology Authors: Stefano Martellucci Letizia Clementi Samantha Sabetta Paola Muzi Vincenzo Mattei Mauro Bologna Adriano Angelucci Source Type: research