Motor and non-motor outcomes of subthalamic deep brain stimulation in a case of juvenile PARK-PINK1

Deep brain stimulation (DBS) is an established therapy for advanced Parkinson Disease (PD). The widespread application of DBS and the advancement in research on PD genetics has raised interest in understanding whether a differential treatment response in PD patients might be influenced by underlying genetic mutations [1,2]. To date, the literature reports mostly on patients with frequent mutations. Although PINK1 (PTEN-induced putative kinase 1) is the second most common (2 –7% of cases) genetic mutation associated with early-onset PD, the outcome of DBS has only been described in two patients with homozygous PINK-1 mutations so far [3,4].

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - April 5, 2021 Category: Neurology Authors: Roberta Balestrino, Claudia Ledda, Alberto Romagnolo, Marco Bozzali, Giovanni Giulietti, Elisa Montanaro, Mario Rizzone, Maurizio Zibetti, Carlo Alberto Artusi, Leonardo Lopiano Source Type: research