Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer ’s disease: a systematic review and meta-analysis

AbstractA lack of convenient and reliable biomarkers for diagnosis and prognosis is a common challenge for neurodegenerative diseases such as Alzheimer ’s disease (AD). Recent advancement in ultrasensitive protein assays has allowed the quantification of tau and phosphorylated tau proteins in peripheral plasma. Here we identified 66 eligible studies reporting quantification of plasma tau and phosphorylated tau 181 (ptau181) using four ultrasensit ive methods. Meta-analysis of these studies confirmed that the AD patients had significantly higher plasma tau and ptau181 levels compared with controls, and that the plasma tau and ptau181 could predict AD with high-accuracy area under curve of the Receiver Operating Characteristic. Therefore, plas ma tau and plasma ptau181 can be considered as biomarkers for AD diagnosis.

Source: Translational Neurodegeneration - March 12, 2021 Category: Neurology Source Type: research