MiRNA ‐107 contributes to inflammatory pain by down‐regulating GLT‐1 expression in rat spinal dorsal horn

ConclusionsThese results suggest that an increase of miR ‐107 contributes to inflammatory pain through downregulating GLT‐1 expression, implying a promising strategy for pain therapy.SignificanceThe currently available treatments for inflammatory pain has limited effect even causes severe side effects. MiRNAs may have important diagnostic and therapeutic potential in inflammatory pain. In present study, we show a potential spinal mechanism of allodynia in rat inflammatory pain model induced by CFA. Increased miR ‐107 contribute to inflammatory pain by targeting and downregulating GLT‐1 expression, implying a promising strategy for inflammatory pain.

Source: European Journal of Pain - February 28, 2021 Category: Anesthesiology Authors: Ling Zhang, Rui Wu, Mei ‐Jie Xu, Jie Sha, Guang‐Yin Xu, Jian Wu, Ping‐An Zhang Tags: ORIGINAL ARTICLE Source Type: research