Achieving clinically meaningful quality of life benefits in nocturia takes time: Results from a long ‐term, multicenter phase 3 study of desmopressin in Japanese patients

ConclusionsDesmopressin ODTs (25 and 50  μg) demonstrated long‐term efficacy, improved QoL, and were well tolerated in Japanese male and female patients with nocturia treated for up to 1 year. Clinically meaningful improvements in patients’ QoL, assessed by N‐QoL, sleep quality, and bother, occur later than objective symptom im provements, such as voids.
Source: LUTS: Lower Urinary Tract Symptoms - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Conditions:   Sleep Fragmentation;   Poor Quality Sleep;   Nocturia;   Nocturnal Enuresis Interventions:   Behavioral: Brief behavioral treatment of insomnia (BBTI);   Behavioral: Information-only control (IC) Sponsors:   University of Pittsburgh;   National Institute on Aging (NIA) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, we have made progress in our understanding of pediatric OSA, and we can even recognize factors leading to its development or worsening. However, pediatricians and pediatric subspecialists are often unaware of the advances and the remedies available. PMID: 28738322 [PubMed - in process]
Source: Advances in Oto-Rhino-Laryngology - Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Abstract PURPOSE: Obstructive sleep apnea (OSA) is underdiagnosed in females due to different clinical presentation. We aimed to determine the effect of gender on clinical and polysomnographic features and identify predictors of OSA in women. METHODS: Differences in demographic, clinical, and polysomnographic parameters between 2052 male and 775 female OSA patients were compared. RESULTS: In female OSA patients, age (56.1 ± 9.7 vs. 50.4 ± 11.6 years, p 
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
AbstractPurposeObstructive sleep apnea (OSA) is underdiagnosed in females due to different clinical presentation. We aimed to determine the effect of gender on clinical and polysomnographic features and identify predictors of OSA in women.MethodsDifferences in demographic, clinical, and polysomnographic parameters between 2052 male and 775 female OSA patients were compared.ResultsIn female OSA patients, age (56.1  ± 9.7 vs. 50.4 ± 11.6 years,p 
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
Abstract BackgroundInsomnia and parasomnia are the most commonly seen sleep disorders in childhood. The aim of this study was to determine the prevalence of insomnia and parasomnia in school children in a metropolitan area (Trabzon) of Turkey. This is the first study on this issue in Turkey to use a large sample size. MethodsAn 84‐item questionnaire was administered to 5200 school children from different socioeconomic levels in 10 primary and 10 secondary schools. The questionnaire included items on the symptoms of sleep disorders and the predisposing factors according to The International Classification of Sleep Disorde...
Source: Pediatrics International - Category: Pediatrics Authors: Tags: Original Article Source Type: research
Discussion Sleep is regulated by the homeostatic sleep drive and the circadian system which controls periods of activity and inactivity throughout the day. The circadian rhythm is slightly longer than 24 hours in humans and is controlled by the hypothalmic suprachiasmatic nucleus. When the circadian system and the external environment are misaligned, such that sleep occurs outside of normal times, a circadian rhythm sleep disorder can occur. Everyone experiences disturbances of sleep throughout their lifetime. During adolescence, there is a normal physiologic change so that there is a shift to a later sleep phase for adol...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Abstract BackgroundInsomnia and parasomnia are the most commonly seen sleep disorders in childhood. The aim of this study was determination of the prevalence of insomnia and parasomnia among school children in a metropolitan area (Trabzon) of Turkey. This is the first study in Turkey regarding this topic that includes a large child population. MethodsAn 84‐item questionnaire was administered to 5200 school children from different socioeconomic levels in 10 primary and 10 secondary schools. The questionnaire included items eliciting information about the symptoms of sleep disorders and the factors that predispose to them ...
Source: Pediatrics International - Category: Pediatrics Authors: Tags: Original Article Source Type: research
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