The Shared Genetic Basis of Hyperuricemia, Gout, and Kidney Function

Summary: Increased urate levels and gout correlate with chronic kidney disease with consensus that the primary driver of this relationship is reduced kidney function. However, a comparison of results of genome-wide association studies in serum urate levels and kidney function indicate a more complex situation. Approximately 20% of loci are shared —comprised of those in which the urate-raising allele associates with reduced kidney function, the vice versa situation, and those in which the signals/alleles are different.

Source: Seminars in Nephrology - November 1, 2020 Category: Urology & Nephrology Authors: Megan P. Leask, Nicholas A. Sumpter, Alexa S. Lupi, Ana I. Vazquez, Richard J. Reynolds, David B. Mount, Tony R. Merriman Source Type: research