Low maternal vitamin A intake increases the incidence of teratogen induced congenital diaphragmatic hernia in mice

CONCLUSION: Low dietary vitamin A intake and marginal vitamin A status lead to an increased incidence of teratogen-induced CDH in mice, highlighting the importance of adequate dietary vitamin A intake and CDH risk.IMPACT: This study describes and validates a mouse model of altered maternal and fetal vitamin A status. This study links existing epidemiological data with a mouse model of teratogen-induced congenital diaphragmatic hernia, highlighting the importance of low maternal vitamin A intake as a risk factor for the development of congenital diaphragmatic hernia. This study supports the Retinoid Hypothesis, which posits that the etiology of congenital diaphragmatic hernia is linked to abnormal retinoid signaling in the developing diaphragm.PMID:33654278 | DOI:10.1038/s41390-021-01409-6

Source: Pediatric Research - March 3, 2021 Category: Pediatrics Authors: Ayanna W Rocke Tianna G Clarke Timothy R A Dalmer Sydney A McCluskey Juan F Garcia Rivas Robin D Clugston Source Type: research