Human growth hormone proteoform pattern changes in pituitary adenomas: Potential biomarkers for 3P medical approaches

ConclusionThese findings provide the first hGH proteoform pattern changes in GH-secreting pituitary adenoma tissues compared to control pituitary tissues, and the status of partial PTMs in hGH proteoforms. Those data provide in-depth insights into biological roles of hGH in GH-related diseases, and identify hGH proteoform pattern biomarkers for treatment of a GH-secreting pituitary adenoma in the context of 3P medicine –predictive diagnostics, targeted prevention, and personalization of medical services.
Source: EPMA Journal - Category: International Medicine & Public Health Source Type: research