Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease

This study has demonstrated alcohol metabolism in LSECs by CYP2E1 and shown that alcohol-induced Hsp90 acetylation is a driver of LSEC dysfunction and liver injury. This study has also demonstrated that blocking this process through deacetylation of Hsp90 by HDAC6 ameliorates LSEC dysfunction and alcohol-induced liver injury.

Source: Journal of Hepatology - March 3, 2021 Category: Gastroenterology Authors: Yilin Yang, Panjamaporn Sangwung, Reiichiro Kondo, Yirang Jung, Matthew J. McConnell, Jain Jeong, Teruo Utsumi, William C. Sessa, Yasuko Iwakiri Source Type: research