A significant association between CXCL10 -1447 A   & gt;  G and IL18 -607 C  & gt;  A gene polymorphism with human T-cell lymphotropic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM-TSP), a case-control report from city of Mashhad, Iran

This study des igned to examine the association between several important gene polymorphisms and HAM-TSP. Genotypes of 232 samples from controls, HTLV-1 carriers, and HAM-TSP patients were examined for FAS-670 (A >  G), CXCL10-1447 (A >  G), Foxp3-3279 (C >  A), IL-18 -137 (C >  G), and IL-18 -607 (C >  A) gene polymorphisms by different polymerase chain reaction (PCR) techniques. A non-significant association was observed between FAS-670 A >  G, Foxp3-3279 C >  A, and IL-18 -137 C >  G gene polymorphisms and HAM-TSP. Nevertheless, a significant (P <  0.001) association between CXCL10-1447 A >  G and IL-18 -607 C >  A gene polymorphisms with HAM-TSP was observed in our study population. As previous studies revealed that the CXCL10 level in the cerebrospinal fluid of HAM-TSP patients was associated with the disease progression, and as we noticed, a direct association was observed between CXCL10-1447 A >  G polymorphism and HAM-TSP. These polymorphisms might be recommended as a valuable prediction criterion for the severity of the disease. The contradiction between our findings and other studies regarding IL-18 -607 C >  A gene polymorphism might be associated with various factors such as genotypes frequency in diverse races and population heterogeneity in the city of Mashhad.
Source: Journal of NeuroVirology - Category: Neurology Source Type: research